Week 12 2021: CFB Picks from the Barstool Sports College Pick’em podcast!
Dave Portnoy:
| Hawaii + 2.5 vs Colorado State |
| Army -37 vs Massachusetts |
| Alabama -21 vs Arkansas |
| SMU + 11 vs Cincinnati |
| Kansas State + 1 vs Baylor |
| Virginia Tech + 7.5 vs Miami (FL) |
| Michigan State + 19.5 vs Ohio State |
| Ohio State vs Michigan State Over 67.5 |
| Ole Miss -36 vs Vanderbilt |
| Ole Miss vs Vanderbilt Over 64 |
| Oregon State + 3 vs Arizona State |
| Oregon State vs Arizona State Over 60 |
| Virginia + 14.5 vs Pittsburgh |
| Pittsburgh vs Virginia Over 66 |
| UCF -31 vs Connecticut |
| Utah -3 vs Oregon |
| Utah vs Oregon Over 58.5 |
| UNLV + 11 vs San Diego State |
Dan Katz:
| Navy + 4 vs East Carolina |
| Alabama -21 vs Arkansas |
| Boise State -27.5 vs New Mexico |
| Boston College -2.5 vs Florida State |
| SMU + 11 vs Cincinnati |
| Cincinnati vs SMU Over 65 |
| Clemson -4 vs Wake Forest |
| Minnesota -7 vs Indiana |
| Kansas State + 1.5 vs Baylor |
| Virginia Tech + 7.5 vs Miami (FL) |
| Missouri vs Florida Over 67.5 |
| Purdue -11.5 vs Northwestern |
| Ohio State vs Michigan State Over 67.5 |
| Ohio State -19.5 vs Michigan State |
| Iowa State + 4 vs Oklahoma |
| Penn State vs Rutgers Under 46.5 |
| California -1.5 vs Stanford |
| South Alabama + 28.5 vs Tennessee |
| UCF vs Connecticut Under 56 |
| UCLA -3 vs Southern Cal |
| Oregon + 3 vs Utah |
| UNLV + 11 vs San Diego State |
| Louisiana Tech -16.5 vs Southern Miss |
| Air Force + 1.5 vs Nevada |
| Louisville -20 vs Duke |
| Central Michigan -2.5 vs Ball State |
| Buffalo vs Northern Illinois Over 59 |
| Eastern Michigan vs Western Michigan Over 66.5 |
| Eastern Michigan + 6 vs Western Michigan |
| Miami (OH) vs Bowling Green Over 52 |
| Miami (OH) -17 vs Bowling Green |
| Ohio vs Toledo Over 57 |
| Toledo -7 vs Ohio |
Rico Bosco:
| Army -37.5 vs Massachusetts |
| Akron vs Kent State Over 74 |
| Alabama -21 vs Arkansas |
| Boise State -27.5 vs New Mexico |
| SMU + 11 vs Cincinnati |
| Kansas State + 1 vs Baylor |
| Virginia Tech + 7.5 vs Miami (FL) |
| Purdue -11.5 vs Northwestern |
| Ohio State vs Michigan State Over 67.5 |
| Connecticut + 31 vs UCF |
| Utah -3 vs Oregon |
| UNLV + 11 vs San Diego State |
| Houston vs Memphis Over 61 |